资深特工伊森·亨特（汤姆·克鲁斯 Tom Cruise 饰）也有百密一疏时刻，他在接收最新任务时遭到神秘组织“辛迪加”的暗算落入对方手中。辛迪加是一支由全球各地前特工组成的秘密组织，此前一直被CIA视为空穴来风。在对方成员伊莎·福斯特（丽贝卡·弗格森 Rebecca Ferguson 饰）的帮助下，伊森逃出生天，并及时向威廉?布莱德（杰瑞米·雷纳 Jeremy Renner 饰）汇报了辛迪加确切存在的消息。然而此时布莱德的日子并不好过，他负责的IMF机构因俄罗斯核弹头等事件遭到CIA指控并责令解散。在得知该组织密谋刺杀奥地利总统时，伊森联系上了老搭档班吉·邓恩（西蒙·佩吉 Simon Pegg 饰）展开行动，并于谜样女郎伊莎再度相会。
接下来的一连串事件中，辛迪加的真面目逐渐揭开，而他们也终于显露出真实的目的……
25 February 2022. War-torn Ukraine. Seventeen-year-old hearing-impaired Olga, along with her father Roman, stepmother Marina and younger brother Sashko, is about to embark on a dangerous journey to the west of the country to escape the advancing Russian forces. However, their house is suddenly occupied by enemy soldiers. The intruders intimidate the family and subject them to s...
Debt-ridden pacifist Richard Fyre is propositioned to return to his abandoned mercenary ways by flamboyant zealot, Priest, to eliminate his international competition in exchange for a clean slate.
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