故事发生在一个电脑科技极为发达的年代，一名科学家发明了一个杀人程序协助警方办案，其中集结了数百名连环杀手的资料和他们的作案手法。这个程序是如此的邪恶，最后不仅生成了个人意志，更拥有了人类的外表和可以随时修复任意损伤的特殊能力，它从禁锢中逃脱了出来，在世间作恶。 为了捕捉这位邪恶的“凶手”，警方设计了一个追踪仪器，罪犯帕克（丹泽尔·华盛顿 Denzel Washington 饰）被选中成为了仪器的试验品。帕克曾经亦是一名警察，却因为动用私刑杀死了让他家破人亡的杀手而被免除了职务打入大牢。而让帕克感到在意的是，在杀人程序中，亦有当年杀害他家人的那名杀手的存在。
A businessman's grand Las Vegas party is halted by a mysterious fog, driving him and his guests into his secret bunker as a sinister presence threatens them.
In Italy, old, dirty, congested prisons full of violence and abuse are a dim and distant memory. Now prisoners serve their sentences in a state of deep sleep which renders them inoffensive and has drastically reduced reoffending rates. Hypersleep is an efficient, economically viable and reliable system. That is, until the day when David Damiani (Stefano Accorsi), a psychologist charged with monitoring prisoners’ mental states, finds himself faced with a prisoner about whom all information has been lost. It’s an unexpected event which triggers a chain of unforeseeable event, forcing David to face up to the ghosts of his very own past.
Four men working at a remote scientific outpost unravel the disturbing secrets about the facility's history, signaling the approach of a mysterious menace that will not only consume these men, but, perhaps, everyone on the planet.
In a dystopian future where all of humanity's memories have become government-regulated transactional products, mankind's crown-jewel memory is stolen - the answer to where we come from.
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