托马斯（迪伦·欧布莱恩 Dylan O'Brien 饰）、米诺（李基弘 Ki Hong Lee 饰）一行人被带到一座神秘的庇护所，这个机构由表里不一的詹森（艾丹·吉伦 Aidan Gillen 饰）所管理，詹森为他们提供安稳且舒适的环境，并下令让幽地斗士们在医疗实验室中接受一连串的测试，詹森向托马斯保证将会把他们送到更加安全的保护区与其他对“闪焰症病毒”免疫的年轻人一同居住。察觉事有蹊跷的托马斯决定再次带领他的伙伴们逃出詹森的掌控，然而等待他们的，却是比迷宫更加危险的焦土。 影片改编自詹姆斯·达什纳撰写的同名反乌托邦科幻小说三部曲的第二部。
In Italy, old, dirty, congested prisons full of violence and abuse are a dim and distant memory. Now prisoners serve their sentences in a state of deep sleep which renders them inoffensive and has drastically reduced reoffending rates. Hypersleep is an efficient, economically viable and reliable system. That is, until the day when David Damiani (Stefano Accorsi), a psychologist charged with monitoring prisoners’ mental states, finds himself faced with a prisoner about whom all information has been lost. It’s an unexpected event which triggers a chain of unforeseeable event, forcing David to face up to the ghosts of his very own past.
Four men working at a remote scientific outpost unravel the disturbing secrets about the facility's history, signaling the approach of a mysterious menace that will not only consume these men, but, perhaps, everyone on the planet.
In a dystopian future where all of humanity's memories have become government-regulated transactional products, mankind's crown-jewel memory is stolen - the answer to where we come from.
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